Ionizable Lipids & Lipid Nano-particle
Ionizable Lipids & Lipid Nanoparticle
AccuLNP® is a lipid mediated, multi-component system for the delivery of nucleic acids. We have a versatile and diverse library of over several hundred proprietary ionizable lipids.
Which serves as the major component of the delivery system. AccuLNP® can be applied for a variety types of therapeutic applications in the field of genetic medicine.
Our team is actively seeking collaborations with innovators specialized in therapeutic RNA design and synthesis
Our preclinical studies have shown that the composition of the delivery vehicle can be tailored for the encapsulation of different types of nucleic acids (e.g., mRNA, siRNA, self-amplifying RNA and oligonucleotides) to achieve high payload encapsulation efficiency, superior product stability and desirable biological performance.
Unique Features
of AccuLNP®
Delivery Platform
Ionizable Lipids
and LNP
Formulations
Rational lipid design to establish structure-activity relationships
Use artificial intelligence (AI) based techniques to predict biological performance and to accelerate lipid screening
High-throughput screening for efficient formulation evaluation
Proprietary library with hundreds of novel ionizable lipids with desirable biological performance
Tailored formulation composition to fit specific applications of genetic medicine
Organ/Tissue
Targeted Delivery
Organ/tissue targeting moieties are incorporated on LNP surface to improve delivery specificity
Endogenous organ targeting empowered by proprietary ionizable lipids
Manufacturing
Efficiency
Clinical validated equipment for LNP production
Established manufacturing process with comprehensive analytical methods to support drug product development
AccuLNP® Mediated Delivery of Nucleic Acid
Step 1
AccuLNP® reaches a target cell of interest and then is taken up by an endogenous cellular transport pathway to deliver nucleic acids intracellularly
Step 2
Upon entering the cytoplasm, the AccuLNP® then is trapped within the endosome
Step 3
As the endosome matures, the acidity increases activating the pH responsive ionizable lipid within AccuLNP® enabling the release of the payload (nucleic acids) into the cytoplasm, which subsequently exerts its desired therapeutic function
Applications
of AccuLNP®
Delivery Platform
Protein Therapy
& mRNA Vaccines
AccuLNP® delivers mRNA For the following therapies: (1) Protein replacement to restore single protein function (2) Cell reprogramming to modulate cell behavior by expressing growth factors (3) Therapeutic antibodies
Modulating the immune system through mRNA-LNP vaccines
Genome
Editing
AccuLNP® delivers CRISPR components (CAS9 mRNA and sgRNA) to cell for gene editing
CAR T cell
Therapy
AccuLNP® generates transient CAR (chimeric antigen receptor) expression on T cells for cancer immunotherapy (autologous cell therapies)
Targeting the
Tumor Tissue
AccuLNP® can target the tumor tissue through the well known EPR effect and deliver genetic medicine for cancer treatment
Antibody-targeted LNPs (AccuLNP-T®) can reach cancer cells with the complementary receptors
Send us
a message
Empowering precision nanomedicine through innovative drug delivery technologies
© 2024 NanoTech Pharm Inc. All rights reserved.